TNF-Α Protection of Hippocampal Neurons from Kainic Acid Induced Neurodegeneration is Associated with Up-Regulation of Nfκb and AKT as well as Down-Regulation of P38 MAPK Signaling Molecules
نویسندگان
چکیده
Xiang-Yu Zheng1,2, Hong-Liang Zhang1,2, Yang Ruan3, Naheed Amir4, Sheikh Azimullah3, Yi Yang1, Abdu Adem3 and Jie Zhu1,2* 1 Department of Neurology, The First Hospital of Jilin University, China 2 Department of Neurobiology, Karolinska Institutet, Sweden 3 Department of Pathology , College of Basic Medical Science, Jilin University, China 4 Department of Pharmacology, United Arab Emirates University, United Arab Emirate
منابع مشابه
From Division of Neurodegeneration, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden Inflammation and cytokine production in experimental neuroinflammatory disorders
Glutamate excitotoxicity is involved in the pathogenesis of a variety of neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). Kainic acid (KA), an analogue of excitotoxic glutamate, can elicit selective neuronal death in the brain of rodents, of which the pathological changes partially mimic the neurodegenerative disorders in hu...
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